Disease Areas of Collaborative Focus

DISEASE AREAS

Allergic Asthma

Assess your experimental materials for efficacy and mechanism of action in BioModels’ established allergic asthma models. Asthma is a condition in which inflammation of the airways results in difficulty breathing, shortness of breath and wheezing. BioModels’ asthma models capture a spectrum of disease mechanisms, allowing you to select the model most relevant for your hypothesis. The BioModels team is experienced with numerous preclinical rodent allergic asthma models, including acute and chronic models that utilize various common allergens, and diverse experimental endpoints, such as:

  • Bronchoalveolar Lavage (BAL) Cellular Analysis (Differential Counts and Flow Cytometry)
  • Lung Mechanics and Airway Hyperresponsiveness (Flexivent)
  • Histopathology and Immunohistochemistry
  • BAL and Lung Tissue Cytokines
  • Non-specific and Allergen-specific Immunoglobulins
  • Peripheral Lymphoid Organ Immunophenotyping (Flow Cytometry)
  • Lung Immunophenotyping (Flow Cytometry)
  • Custom Assays and Endpoints

Study Models

OVA-Induced Allergic Asthma

OVA-Induced Allergic Asthma

House Dust Mite (HDM)-Induced Allergic Asthma

House Dust Mite (HDM)-Induced Allergic Asthma

Daniel Lichtman

Managing Partner