Disease Areas of Collaborative Focus

Disease Areas

Allergic Diseases

Assess your experimental materials for efficacy and mechanism of action in BioModels’ established preclinical allergic disease models. Allergic diseases, such as allergic asthma, food allergy, and eosinic esophagitis, are conditions in which the immune system overreacts to innocuous environmental antigen (allergen). BioModels’ allergic disease models capture a spectrum of disease mechanisms, allowing you to select the model most relevant for your hypothesis.

The BioModels team is experienced with numerous preclinical rodent allergic disease models, including acute and chronic models that utilize various common allergens, and diverse experimental endpoints, such as:

  • Bronchoalveolar Lavage (BAL) Cellular Analysis (Differential Counts and Flow Cytometry)
  • Lung Mechanics and Airway Hyperresponsiveness (Flexivent)
  • Histopathology and Immunohistochemistry
  • Systemic, BAL, and Tissue-specific Cytokines
  • Anaphylaxis assessment (temperature measurement)
  • Non-specific and Allergen-specific immunoglobulins
  • Peripheral Lymphoid Organ Immunophenotyping (Flow Cytometry)
  • Organ-specific Immunophenotyping (Flow Cytometry)
  • Custom Assays and Endpoints

Study Models

OVA-Induced Allergic Asthma

OVA-Induced Allergic Asthma

House Dust Mite (HDM)-Induced Allergic Asthma

House Dust Mite (HDM)-Induced Allergic Asthma

Eosinophilic Esophagitis (EoE)

Eosinophilic Esophagitis (EoE)

Food Allergy

Food Allergy

Daniel Lichtman

Managing Partner