Disease Areas of Collaborative Focus

Disease Areas

Graft vs Host Disease

Assess your experimental materials for efficacy and mechanism of action in BioModels’ established preclinical GVHD models. For patients undergoing stem cell transplant, GVHD is a significant cause of morbidity and mortality which presents as a heterogeneous condition involving multiple organs. BioModels’ GVHD models allow you to evaluate the immunopathology of post-transplant disease in various organs such as skin, gut, liver, and lung.

The BioModels team is experienced with multiple GVHD model induction paradigms which are available with diverse experimental endpoints, such as:

  • Kaplan-Meier Survival Analysis
  • Body weight
  • Disease Activity Scoring
  • Diarrhea & Bloody Stool Incidence
  • In-life Endoscopy
  • Organ/Tissue Weight & Length
  • Engraftment Assessment (Flow Cytometry)
  • Peripheral Blood/Lymphoid Organ Immunophenotyping (Flow Cytometry)
  • Cytokine Analysis (Tissue and Blood)
  • Histopathology & Immunohistochemistry
  • Custom Assays and Endpoints

Study Models

Acute GVHD (Major MHC Mismatch e.g. Acute GVHD)

Acute GVHD (Major MHC Mismatch e.g. Acute GVHD)

Sclerodermatous Chronic GVHD (Minor MHC Mismatch Sclerodermatous Chronic GVHD)

Sclerodermatous Chronic GVHD (Minor MHC Mismatch Sclerodermatous Chronic GVHD)

Humanized GVHD (PBMC Xenograft- xGVHD)

Humanized GVHD (PBMC Xenograft- xGVHD)

Graft vs Leukemia (GVL)

Graft vs Leukemia (GVL)

 

Daniel Lichtman

Managing Partner