Disease Areas of Collaborative Focus

DISEASE AREAS

Microbiome and Oncology

Assess your experimental microbiome-based test-articles for efficacy and/or mechanism of action with BioModels’ established approaches for modeling microbiome differences and perturbations in animal models of human cancer. The microbiome’s role in both cancer susceptibility and therapeutic response is increasingly appreciated, with particularly robust data supporting the microbiome’s impact on immune checkpoint inhibitor therapy efficacy. BioModels has experience with a number of approaches to model microbiome differences and perturbations for oncology projects, offering diverse experimental solutions such as:

  • Customizable husbandry options ranging from full germ-free barrier paradigms to conventional housing, including isolator housing.
  • In-house microbiology capabilities and expertise

Animal modeling with:

  • Subcutaneous Tumor Measurement via Calipers
  • Systemic or Orthotopic Tumor Measurement (Luciferase-Expressing Lines) via IVIS
  • Body Condition Scoring
  • Assessment of Bacteria Load (culture and qPCR)
  • Sequencing and Metagenomics
  • Peripheral Lymphoid Organ Immunophenotyping (Flow Cytometry)
  • Tumor Infiltrating Lymphocyte Immunophenotyping (Flow Cytometry)
  •  Custom Assays and Endpoints

Study Models

Syngeneic Subcutaneous Melanoma with CPI Treatment – Vendor Comparison

Syngeneic Subcutaneous Melanoma with CPI Treatment – Vendor Comparison

Syngeneic Subcutaneous Melanoma with CPI Treatment – Germ Free

Syngeneic Subcutaneous Melanoma with CPI Treatment – Germ Free

Daniel Lichtman

Managing Partner