Disease Areas of
Collaborative Focus

DISEASE AREAS

Proctitis

Assess your novel therapeutics for efficacy and/or mechanism of action in our established models of radiation-induced proctitis. Radiotherapy is an important method of treatment for many pelvic and GI malignancies. However, with radiation in this region, it can result in the development of acute or even chronic proctitis that can severely impact the patient’s quality of life and ability to tolerate additional cancer treatment. Select the best model, acute or fractionated, based on your potential targets and study goals.

Our literature-validated experimental endpoints include:

  • Body Weight Monitoring
  • Survival
  • In-Life Endoscopy
  • Colon Weight & Length
  • Local and Systemic Cytokine Analysis
  • Terminal Histopathology and/or IHC Analyses
  • Fecal Lipocalin (LCN2), Calprotectin, & Myeloperoxidase (MPO)
  • Custom Assays and Endpoints

Study Models

Acute Radiation-Induced Proctitis

Acute Radiation-Induced Proctitis

Fractionated Radiation-Induced Proctitis

Fractionated Radiation-Induced Proctitis

Daniel Lichtman

Managing Partner