Disease Areas of Collaborative Focus


PK/PD and Toxicology

Pharmacology and toxicology studies are indispensable in the drug development process. These studies provide mission critical data regarding the safety and efficacy of the compound of interest. The planning and execution of programs to investigate the pharmacokinetics, pharmacodynamics, and toxicity of potential drug candidates should be a baseline practice at the pre-clinical stage to help better inform downstream regulatory applications and clinical trial designs.

The BioModels technical team is trained with all routinely used routes of administration for in vivo studies including the following with alternative routes available upon request:

  • Oral Gavage (PO)
  • Intravenous (IV)
  • Subcutaneous (SC)
  • Intraperitoneal (IP)
  • Intranasal (IN)/intratracheal (IT)/pulmonary
  • Topical
  • Intramuscular (IM)
  • Intrarectal (IR)
  • Oral Capsule Dosing (Rats)
  • Aerosol Inhalation
  • Intratibular
  • Intracecal (IC) – see surgery capabilities (link)

BioModels is fully equipped to perform PK/PD and non-GLP toxicology studies to support any drug development program with customizable experimental endpoints such as:

  • Biodistribution and Drug Transit Time
  • Predictive Biomarker Identification and Assessment
  • Maximum Tolerated Dose and Incremental Toxicity Levels

Daniel Lichtman

Managing Partner