Disease Areas of Collaborative Focus

Disease Areas

Colitis and Inflammatory Bowel
Disease Models

Assess your experimental materials for efficacy and mechanism of action in BioModels’ established preclinical IBD/colitis models. Crohn’s Disease and Ulcerative Colitis, collectively considered IBD, are chronic intestinal disorders affecting approximately 1.4 million Americans. BioModels’ colitis models capture a spectrum of disease mechanisms, allowing you to select the model most relevant for your hypothesis. The BioModels team is experienced with numerous preclinical colitis animal models, including chemically induced and immune-mediated models, and diverse experimental endpoints, such as:

  • Weight Loss & Disease Activity Index
  • In-Life Endoscopy
  • Colon Weight & Length
  • Colon and Plasma/Serum Cytokines
  • Fecal Lipocalin (LCN2), Calprotectin, & Myeloperoxidase (MPO)
  • Peripheral Lymphoid Organ Immunophenotyping (Flow Cytometry)
  • Colon Lamina Propria Immunophenotyping (Flow Cytometry)
  • Custom Assays and Endpoints

Study Models

Semi-Acute Dextran Sulfate Sodium (DSS)-Induced Colitis (10-21 Day)

Semi-Acute Dextran Sulfate Sodium (DSS)-Induced Colitis (10-21 Day)

Chronic Dextran Sulfate Sodium (DSS)-Induced Colitis (35 Day)

Chronic Dextran Sulfate Sodium (DSS)-Induced Colitis (35 Day)

Trinitrobenzene Sulfonic Acid (TNBS)-Induced Colitis

Trinitrobenzene Sulfonic Acid (TNBS)-Induced Colitis

Oxazolone (OXZ)-Induced Colitis

Oxazolone (OXZ)-Induced Colitis

CD40 mAb-Induced Colitis

CD40 mAb-Induced Colitis

Naïve T Cell Transfer Induced Colitis

Naïve T Cell Transfer Induced Colitis

Germ-Free IL-10 Knockout Colitis

Germ-Free IL-10 Knockout Colitis

Proctitis

Proctitis

 

Daniel Lichtman

Managing Partner