Disease Areas of Collaborative Focus

Disease Areas

Multiple Sclerosis

Assess your experimental materials for efficacy and mechanism of action in BioModels’ established preclinical Experimental Autoimmune Encephalomyelitis (EAE) models of Multiple Sclerosis (MS). MS, the most common neurological disease of young adults, is an inflammatory, T-cell mediated autoimmune disease of the central nervous system (CNS). BioModels’ EAE models are T cell mediated, and stimulation of an immune responses against CNS antigens is the underlying mechanism of the model.

The BioModels team is experienced with both the MOG induced model of chronic EAE as well as the PLP model of relapsing EAE; both are available with diverse endpoint assessment such as:

  • Weight Loss
  • EAE Scoring and Disease Incidence
  • Central Nervous System (CNS) Histopathology (H&E/LFB) and IHC
  • CNS and Plasma/Serum Cytokines
  • Peripheral Lymphoid Organ Immunophenotyping (Flow Cytometry)
  • CNS Immunophenotyping (Flow Cytometry)
  • Custom Assays and Endpoints

Study Models

MOG Induced Experimental Autoimmune Encephalomyelitis (Chronic EAE)

MOG Induced Experimental Autoimmune Encephalomyelitis (Chronic EAE)

PLP Induced Experimental Autoimmune Encephalomyelitis (Relapsing EAE)

PLP Induced Experimental Autoimmune Encephalomyelitis (Relapsing EAE)

Daniel Lichtman

Managing Partner