Cell and Molecular Biology
Murine/Rat Cancer Cell Lines Validated In Vivo
Indication | Cell Lines | Readouts |
Blood Cancers | A20, EL4, L1210 |
|
Breast Cancer |
4T1, Walker 256 (rat), *4T1-Luc |
|
Colorectal Cancer | CT-26 | |
Brain Cancer |
GL261, F98 (rat), *GL261-Luc |
|
Lung Cancer | LLC-1 | |
Melanoma | B16.F0, B16.F10, B16.F10.SIY | |
Sarcoma | Yoshida | |
Treatments: Chemotherapies, Radiotherapies, Immunotherapies |
*Indicates Bioluminescent Cell Lines
Human Cancer Cell Lines Validated In Vivo
Indication | Cell Lines | Readouts |
Blood Cancers |
CCRF-CEM, CEM, Daudi, Jeko-1, Jurkat, Kasumi-1, KG-1, Molt-4, Raji, Ramos, Reh, RPMI8226, THP-1, Z-138 |
|
Breast Cancer |
MDA-MB-231, MDA-MB-468, *HBCx-14-Luc1, *MDA-MB-231-Luc |
|
Colorectal Cancer |
HCT-15, HCT-116, HT-29, *HCT-116-Luc, *HT-29-Luc |
|
Brain Cancer | IMR-32, U87-MG, U118-MG | |
Head and Neck Cancer |
Cal-27, FaDu, SCC-25, SCC-154, *FaDu-Luc, *SCC-25-Luc | |
Liver Cancer | HepG2, Hep3B | |
Lung Cancer |
A549, H69, H82, H460, H520, H1299, H146, *H460-Luc |
|
Melanoma |
SK-MEL-28, *SK-MEL-28-Luc, *MELx-006-Luc1 |
|
Ovarian Cancer |
OVCAR-3, *OVA21-DMT-Luc |
|
Pancreatic Cancer | AsPC-1, BxPC3, MIA PaCa-2, Panc-1 | |
Prostate Cancer | DU-145, PC-3 | |
Renal Cancer | 786-0, A498 | |
Stomach Cancer | N-87 | |
Treatments: Chemotherapies, Radiotherapies, Immunotherapies |
*Indicates Bioluminescent Cell Lines
Ability to analyze up to seven parameters simultaneously. For use in the detailed characterization of multiple cell types, assessment of cytokine production, intra-cellular signaling, and evaluation of the purity of cell populations. Relevant to any model in which a particular cell type needs to be identified and/or characterized. For example, assessing tumor infiltrating leukocytes in oncology models, activation of lymphocytes following drug delivery, and tracking engraftment in adoptive transfer models.
Uses magnetic cell separation technology to enrich specific sub populations from a wide variety of cell types based on expression or absence of specific surface markers. For example, bone marrow preparations can be depleted of CD4+ T cells prior to adoptive transfer in GVHD models, and naïve T cells can be purified from spleen preparations for use in colitis models.
Used commonly in molecular biology to detect RNA expression; our capabilities include PCR, RT-PCR, qPCR, and qRT-PCR.