Presented By: Caitlin Parello and Jessica Durrant
Description:
Fibrosis in Inflammatory Bowel Disease (IBD), particularly Crohn’s Disease, remains a significant clinical challenge with no approved therapeutic options. The development of effective non-surgical treatments requires translational preclinical animal models that accurately reflect disease pathology.
Join BioModels and DTR Labs – contract research organizations specializing in preclinical rodent modeling and histopathology – for an in-depth discussion on modeling fibrosis in colitis.
We’ll explore the differences between fibrosis in ulcerative colitis and the fibrostenotic phenotype of Crohn’s Disease, offer guidance on selecting appropriate preclinical models based on experimental goals, and present data from both the murine DSS model and the rat chronic TNBS model.
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