Selecting the Right Colitis Model for Your IBD Research
Model selection plays an important role in aligning your preclinical study with your therapeutic and research objectives. BioModels offers established DSS- and TNBS-induced colitis models in mice and rats, with flexible study designs and a range of endpoints to support diverse IBD research programs.
Acute DSS-Induced Colitis
Robust. Sustained. Flexible.
- One of the most widely published IBD models and commonly used in preclinical drug development
- Available in both mice and rats
- Produces robust, sustained colitis and provides a flexible treatment schedules (prophylactic or therapeutic) for acute through semi-chronic study designs (7-21 Days)
Acute TNBS-Induced Colitis
Rapid. Acute. Defined.
- A well published model in mice and rats, induced by a single intrarectal dose
- Characterized by rapid disease onset, an early disease peak, and gradual recovery
- Well-suited for efficient screening of test articles and evaluation of acute inflammatory responses
- Chronic models also available
Have a study in mind? Our team can help you select the appropriate model and develop a study design aligned with your research objectives.
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