Neuroscience

Neuroscience

BioModels has extensive experience with a variety of animal models that capture critical mechanisms of neurological disorders.  Assess your test articles in established preclinical models of Parkinson’s Disease, Alzheimer Disease, depression, anxiety, fatigue and autism spectrum disorder (ASD) using a range of behavioral assessments coupled with histological and/or molecular endpoints.    

• Evaluate experimental therapeutics in customized and off-the-shelf models of neurological disorders. 
• Determine target engagement and mechanism of action in models that recapitulate complex mechanisms. 
• Utilize behavioral endpoints such as: open field, wheel running, forced exercise, forced swim test, rotarod, novel object recognition, social approach, fear conditioning, elevated plus maze, tail suspension, grip strength and others.   
• Work with the BioModels team to customize or develop models most suitable for your needs. 

Parkinson’s Disease

Assess your experimental materials for efficacy and mechanism of action in BioModels’ established Parkinson’s Disease model. Parkinson’s disease is a neurodegenerative disorder that results in motor dysfunction. BioModels’ Parkinson’s Disease model captures a spectrum of disease phenotypes, including behavioral and histological endpoints.

We offer diverse experimental endpoints, such as:

• Weight Loss
• Motor Dysfunction (Rotarod)
• Various Behavioral Assessments
• Custom Assays and Endpoints

Autism Spectrum Disorder

Assess your novel therapeutics for efficacy in BioModels’ established autism spectrum disorder model. Autism is characterized by impairments in social and communication skills and is diagnosed early in childhood development. BioModels’ autism model allows you to evaluate deficits in social behaviors including social approach, social interaction and abnormal ultrasonic vocalizations.

The BioModels team is experienced with the BTBR autism model which is available with experimental endpoints, such as:

• Sociability Index

Depression

Assess your novel therapeutics for efficacy in BioModels’ established depression models. Major depression is a debilitating mental illness, symptoms can include listlessness, feeling hopeless, thoughts of death or suicide, and anhedonia. BioModels’ depression models allow you to screen potential antidepressant therapies.

The BioModels team is experienced with the forced swim test and tail suspension test which are available with experimental endpoints, such as:

• Time Spent Immobile