The venous thrombosis model can be used to evaluate the impact of anti-coagulants and has been used to evaluate the potential for compounds to increase the propensity for clot formation. In rodents, thrombus is induced by the direct application of a solution of ferric chloride (FeCl3) to the adventitial surface of the femoral vein. Thrombus formation is measured using intravital video microscopy alone or in combination with a laser Doppler flow probe to monitor vessel occlusion. In addition to the primary endpoint of time to complete occlusion, other flow parameters, including a visual evaluation of blood flow using the Thrombolysis in Myocardial Infarction (TIMI) scoring scale, are assessed. In mice, test article responses can be compared to the effects of Lovenox (Enoxaparin sodium).

• C57Bl/6 Mice

• In-life evaluation of blood flow via HD video microscopy
• Time to occlusion
• Doppler flow
• TIMI scoring

• Custom assays