Fatigue related to cancer and cancer treatment is one of the most common symptoms reported by cancer patients. Fatigue negatively impacts quality of life and in some cases may even influence a patients’ decision to continue treatment. BioModels has developed an animal model of chemotherapy-related fatigue in which mice are treated with two cycles of doxorubicin followed by daily evaluation of wheel running activity. Chemotherapy treatment results in a significant reduction in voluntary wheel running activity, typically occurring in the second half of the wake cycle, mimicking patient-reported symptoms. There is currently an unmet need for effective therapies to treat fatigue. No pharmaceutical therapies are currently approved for fatigue.

• Mice

• Percent weight change
• Survival
• Wheel running activity

• Other behavioral endpoints
• Custom assays