Genetic Models of Obesity and Diabetes

Description

There are several well characterized, genetic rodent models of obesity that can be used to identify factors that are contributing to obesity and to assess novel therapeutics for their potential in treating this metabolic disorder.  Additionally, many of these models also exhibit spontaneous Type 1 and Type 2 diabetes and display delayed wound healing.  Some of these preclinical models include Zucker rats (T1D), ZDF rats (T2D), ob/ob mice (T2D) and db/db mice (T2D).  BioModels can provide the expertise necessary to design and execute an obesity study that is customized to meet your specific needs with flexible experimental endpoints.

Model Systems
  • Zucker rats (T1D)
  • ZDF rats (T2D)
  • ob/ob mice (T2D)
  • db/db mice (T2D)
Standard Readouts
  • Percent weight change
  • Bone densitometry (DEXA)
  • Body composition (DEXA)
  • Blood glucose
Additional Readouts
  • Wound healing
  • Blood insulin
  • Glucose or Insulin tolerance testing (GTT or ITT)
  • Histopathology and/or IHC analyses
  • Multiplex/cytokine analysis
  • Peripheral lymphoid organ immunophenotyping
  • Custom assays

Daniel Lichtman

Managing Partner