In the fractionated radiation-induced dermatitis model at BioModels, disease is induced using 6 fractionated, smaller doses of targeted radiation to the skin of mice while the rest of the body is protected by a lead shield. Animals are monitored daily and evaluated for overall health and survival in addition to dermatitis severity over the course of the study. Peak disease typically occurs between Day 14 and Day 16, with disease persisting through the final evaluation which typically includes histopathology.

• Advantages: good for screening potential drug candidates, consistent disease incidence, higher clinical relevance with multiple radiation treatments, severity can be modulated using different radiation doses.
• Disadvantages: longer duration than acute model.

• BALB/c Mice

• Percent weight change
• Survival
• In-life dermatitis evaluation
• Terminal histopathology and/or IHC analyses

• Tissue localized protein analyses
• Peripheral lymphoid organ immunophenotyping
• Gene expression
• Custom assays