At BioModels, you can assess your novel therapeutics for efficacy and mechanism of action in our established chemotherapy-induced myelosuppression model to address an unmet clinical need for patients. Cytotoxic chemotherapy drugs can lower cell levels in the bone marrow, resulting in abnormally low number of cells in the blood leading to symptoms that may result in reduction or breaks in cancer treatments. Myelosuppression is induced in mice or rats with one or two cycles of Doxorubicin. Animals are assessed daily over the course of the study for survival and weight change. Other important readouts include complete blood counts and bone marrow histology.

• Mice and Rats

• Percent weight change
• Survival
• Red blood cell count
• White blood cell count
• Bone marrow histopathology and/or IHC analyses

• Tissue localized protein analyses
• Gene expression
• Custom assays