The arterial thrombosis model can be used to compare the anti-thrombogenic activities of novel therapeutics to provide a pre-clinical means of assessing the potential benefits of new drugs and drug combinations in reducing the risk of arterial thrombosis. In rodents, thrombus is induced by the direct application of a solution of ferric chloride (FeCl3) to the adventitial surface of the carotid artery. Thrombus formation is measured using intravital video microscopy alone or in combination with a laser Doppler flow probe to monitor vessel occlusion. In addition to the primary endpoint of time to complete occlusion, other flow parameters, including a visual evaluation of blood flow using the Thrombolysis in Myocardial Infarction (TIMI) scoring scale, are assessed.

• C57Bl/6 Mice

• In-life evaluation of blood flow via HD video microscopy
• Time to occlusion
• Doppler flow
• TIMI scoring

• Custom assays