In some experimental cases, it is advantageous to utilize more common laboratory animal species such as rats or mice due to the increased availability of regents or genetic variants. BioModels has developed an acute radiation model of oral mucositis in both mice and rats that results in ulceration of the oral mucosa that can be assessed via visual scoring that uses a validated scoring scale and/or histopathology. Contact BioModels to discuss the models in more detail and to customize the approach to meet your study goals.

• Advantages: utilize more common laboratory species (use of genetically modified animals- knockouts).
• Disadvantages: less clinically relevant, more difficult to dose topical therapies.