Clinically Relevant Animal Models of Fibrosis: Utilizing Classical and Novel Approaches to Evaluate Potential Therapies

Presented By: 
Andrew Borkowski

Overview: Fibrosis is a common and debilitating process that drives a number of human diseases. It has been estimated that ~45% of all deaths in the US are due to fibrotic disorders, in which once healthy tissue is subjected to chronic inflammation resulting in excess accumulation of extracellular matrix and collagen, leading to scar tissue buildup that ultimately results in altered organ function or failure. These disorders can occur in major organs and fibrotic diseases include idiopathic pulmonary fibrosis, cirrhosis of the liver, chronic kidney disease, scleroderma, and many others. While it is well known that common pathways are activated and drive these diseases, there is still an unmet need for effective therapeutics for fibrotic disease.

This webinar will showcase translational and predictive animal models of fibrotic disease. Additionally, the webinar will provide an overview of each clinical condition and how the utilization of both traditional and functional analyses in our animal models result in outcomes that will best predict how your therapeutic will behave in the clinic.

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