Released on April 01, 2017

Oral mucositis remains one of the most dominant, serious, disruptive, and symptomatic complications of radiation therapy used for the treatment of cancers of the head and neck (Villa and Sonis, 2015).  Progressive mucosal injury accompanies increasing daily radiation fractions until...

Released on April 01, 2017

Objectives: Dacomitinib is a pan-HER inhibitor for advanced non-small-cell lung cancer (NSCLC).  We explored the impact of a planned 4-day dacomitinib dose interruption on plasma exposure of dacomitinib and adverse events (AEs) of interest in Cohort III of the ARCHER 1042 study. Materials...

Released on January 13, 2017

Objective: mTOR inhibitor treatment of solid cancers is associated with mTOR inhibitor-associated stomatitis (mIAS) a common, significant, dose-limiting toxicity, with aphthous-like lesions.  Our objective was to assess the utility of a new organotypic model in defining mIAS’ pathogenesis...

Released on January 01, 2017

Background: B-cell chronic lymphocytic leukemia (CLL) is a heterogeneous disease and the most common adult leukemia in western countries.  IgVH mutational status distinguishes two major types of CLL, each associated with a different prognosis and survival.  Sequencing identified NOTCH1...

Released on December 15, 2016

Neurotoxicity is a common side effect of chemotherapy treatment, with unclear molecular mechanisms. Clinical studies suggest that the most frequent neurotoxic adverse events affect memory and learning, attention, concentration, processing speeds and executive function. Emerging preclinical...

Released on December 10, 2016

Dusquetide, a novel Innate Defense Regulator, modulates the innate immune system at a key convergence point in intracellular signaling pathways and has demonstrated activity in both reducing inflammation and increasing clearance of bacterial infection.  Innate immunity has also been...

Released on December 01, 2016

Introduction: It has become clear that noise generated during the assay and analytical processes has the ability to disrupt accurate interpretation of genomic studies.  Not only does such noise impact the scientific validity and costs of studies, but when assessed in the context of...

Released on December 01, 2016

To better understand the impact of microarray preprocessing normalization techniques on the analysis of biological pathways in the prediction of chronic fatigue (CF) following radiation therapy, this study has compared the list of predictive genes found using the Robust Multiarray Averaging (RMA...

Released on September 01, 2016

Approximately 600,000 new cases of head and neck cancer (HNC) would be diagnosed worldwide this year.  Of those, a bit less than 10% would occur in the United States.  Most of these neoplasms would be histologically diagnosed as a squamous cell carcinomas for which the preferred...

Released on September 01, 2016

Introduction: Oral mucositis is a frequent and devastating toxicity secondary to cancer treatment, which may affect 20-40% of patients receiving conventional chemotherapy and 60-85% of patients undergoing hematopoietic stem cell transplantation.  The pathobiology of mucositis includes a...