Personalizing Supportive Care: Pharmacogenomics and Risk Prediction

AuthorsStephen Sonis
PublishedMay 26, 2016
JournalASCO Daily News


The importance of treatment-related side effects in impeding effective cancer therapy was recognized in the recently articulated “cancer moonshot” initiative. Regimen-related toxicities impact the overall success of treatment outcomes—in some sense, a tail capable of wagging the dog. To truly impact the tolerability of treatment, effective, personalized, biologically-based prevention of side effects is more desirable than reactive palliative management. Not only does such an approach mitigate the miseries associated with cytotoxic or targeted regimens in a cost-effective way, but it opens a window for even more aggressive and definitive cancer treatment.

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