Released on October 13, 2017

Many breast cancer (BC) patients treated with aromatase inhibitors (AIs) develop aromatase inhibitor-related arthralgia (AIA).  Candidate gene studies to identify AIA risk are limited in scope.  We evaluated the potential of a novel analytic algorithm (NAA) to predict AIA using germline...

Released on May 01, 2015

The successes of the Human Genome Project catalyzed the transition of genomics from the laboratory to the clinic. Over the past decade, there has been a proliferation of studies demonstrating the potential utility of various applications of genomics as a conduit to accelerate drug development,...

Released on December 01, 2016

To better understand the impact of microarray preprocessing normalization techniques on the analysis of biological pathways in the prediction of chronic fatigue (CF) following radiation therapy, this study has compared the list of predictive genes found using the Robust Multiarray Averaging (RMA)...

Released on December 01, 2016

Introduction: It has become clear that noise generated during the assay and analytical processes has the ability to disrupt accurate interpretation of genomic studies.  Not only does such noise impact the scientific validity and costs of studies, but when assessed in the context of clinically...

Released on January 01, 2017

Background: B-cell chronic lymphocytic leukemia (CLL) is a heterogeneous disease and the most common adult leukemia in western countries.  IgVH mutational status distinguishes two major types of CLL, each associated with a different prognosis and survival.  Sequencing identified NOTCH1...

Released on March 01, 2007

Patients treated with radiotherapy are prone to a constellation of local and systemic toxicities including mucositis, xerostomia, fatigue and anorexia. The biological complexities and similarities underlying the development of toxicities have recently been realized. Mucosal barrier injury is one of...

Released on August 06, 2011

Gamma-d-glutamyl-l-tryptophan (SCV-07) demonstrated an overall efficacy signal in ameliorating oral mucositis (OM) in a clinical trial of head and neck cancer patients. However, not all SCV-07-treated subjects responded positively. Here we determined if specific gene clusters could discriminate...

Released on August 27, 2016

Genomics has been used with varying degrees of success in the context of drug discovery and in defining mechanisms of action for diseases like cancer and neurodegenerative and rare diseases in the quest for orphan drugs. To improve its utility, accuracy, and cost-effectiveness optimization of...