Could the PI3K Canonical Pathway Be A Common Link Between Chronic Inflammatory Conditions and Oral Carcinogenesis?

AuthorsStephen Sonis, Rui Amaral Mendes
PublishedMarch 15, 2016
JournalJournal of Oral Pathology & Medicine


The association between chronic inflammatory disorders and oral carcinogenesis has been both a source of interest and contention. Based upon its central importance in oral carcinogenesis, the finding that the PI3k/Akt/mTOR pathway is activated in oral lichen planus, chronic graft-versus-host disease, and chronic oral candidiasis suggests that it may provide a link between benign and malignant oral conditions. Here, we discuss a possible mechanistic rationale that addresses the activation of this important signaling pathway and its downstream events, while correlating it with the carcinogenic potential of chronic oral disorders.

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