Released on May 01, 2014

Background: The objective of this trial was to determine how a mucoadhesive hydrogel (MuGard), a marketed medical device, would fare when tested with the strictness of a conventional multi-institutional, double-blind, randomized, placebo-contolled study format. Methods: A total of 120 subjects...

Released on October 01, 2014

Background: Diarrhea is a common toxicity of chemotherapy, but the practice of reporting only severe grades (≥ 3) in clinical trials results in misleading conclusions of significance.  Epidemiology remains poorly described, and effects of multi-cycle regimens have not been investigated....

Released on September 01, 2014

Introduction: Oral mucositis remains a common, symptomatically devastating toxicity of common drug and radiation regimens used to treat cancer.  The current limited treatment options are likely to be supplemented by an active pipeline in which innovative compounds are being developed which...

Released on February 01, 2015

Purpose: To better understand the indirect effects of standard courses of radiation therapy (RT) on distant tissue toxicity, we evaluated the frequency, course, and health and economic burden of regimen-related diarrhea in a large, multinational group of patients who were being treated for cancers...

Released on November 04, 2014

Objectives: Oral Mucositis (OM) is a painful complication of radiation therapy (RT) for head and neck cancer (H&NC).  OM can compromise nurtrition, require opioid analgesics and hospitalization for pain control, and lead to treatment interruptions.  Based on the role of inflammatory...

Released on December 01, 2014

Background: Fatigue is a common side effect of cancer (CA) treatment. We used a novel analytical method to identify and validate a specific gene cluster that is predictive of fatigue risk in prostate cancer patients (PCP) treated with radiotherapy (RT). Methods: A total of 44 PCP were categorized...

Released on May 01, 2015

Purpose of Review: Oral mucositis remains a frequent debilitating toxicity associated with drug and radiation regimens used to treat cancer. This review highlights the recent understanding of the biological basis, risk factors for, and management for oral mucositis. Recent Findings: Prevalence and...

Released on May 01, 2015

The successes of the Human Genome Project catalyzed the transition of genomics from the laboratory to the clinic. Over the past decade, there has been a proliferation of studies demonstrating the potential utility of various applications of genomics as a conduit to accelerate drug development,...

Released on December 15, 2016

Neurotoxicity is a common side effect of chemotherapy treatment, with unclear molecular mechanisms. Clinical studies suggest that the most frequent neurotoxic adverse events affect memory and learning, attention, concentration, processing speeds and executive function. Emerging preclinical research...

Released on September 01, 2016

Introduction: Oral mucositis is a frequent and devastating toxicity secondary to cancer treatment, which may affect 20-40% of patients receiving conventional chemotherapy and 60-85% of patients undergoing hematopoietic stem cell transplantation.  The pathobiology of mucositis includes a...