Radiation Countermeasures

The acute illness caused by exposure to a high dose of penetrating radiation to the body is referred to as the Acute Radiation Syndrome (ARS). There are three classical ARS syndromes: bone marrow syndrome (also referred to as hematopoietic syndrome), gastrointestinal syndrome (GI-ARS), and cardiovascular (CV)/central nervous system (CNS) syndrome.

In humans, bone marrow syndrome can occur with a dose of > 0.7 Gy, while GI-ARS usually occurs at much higher doses (greater than 10 Gy). In GI-ARS, the symptoms typically include anorexia, severe nausea, vomiting, cramps and diarrhea.  Subjects with this syndrome usually die within 2 weeks. The cause of death is usually infection, dehydration and electrolyte imbalance as a result of destructive changes in the GI tract and bone marrow. CV/CNS syndrome occurs as a result of exposure to very high dose of greater than 50 Gy and all subjects are expected to die from this syndrome. Biomodels has developed several models of animal model of acute radiation exposure to test therapeutics designed to prevent radiation toxicity-associated mortality. 

Subscribe to RSS - Radiation Countermeasures