Chemotherapy-Induced Diarrhea
Diarrhea is one of the most common toxicities associated with chemotherapy, reported in up to 80% of patients. Uncontrolled CID can result in serious physical (dehydration, electrolyte imbalance, renal insufficiency, immune dysfunction, disruption of treatment, and even death), emotional (anxiety depression, caregiver strain) and economic (hospitalization) outcomes. For these reasons, the effects of CID can be devastating to patients.
Biomodels’ Chemotherapy Induced Diarrhea (CID) model utilizes well validated dose concentrations and schedules of common chemotherapeutic agents to reproducibly induce diarrhea of known duration and severity in rats or mice.
Study Design Table
Model | Description | Duration | In-Life Analyses |
---|---|---|---|
Chemotherapy-Induced Diarrhea (CID) | Diarrhea is induced by treatment with 5-FU, irinotecan, or other chemotherapy in rats or mice. | 7 Days | Daily weight change, Daily stool consistency scoring, Video endoscopy, Food/water consumption |
Representative data below, click images to enlarge.